Terbogrel, A Dual-Acting Agent For Thromboxane Receptor Antagonism And Thromboxane Synthase Inhibition

Terbogrel,双效剂,血栓素受体拮抗作用,抑制血栓素合成酶 注:没有中文版本,只有英文版本
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Abstract: Terbogrel, (E)-6-[4-(3-tert-butyl-2-cyano­guanidino)­phenyl]-6-(3-pyridyl)­hex-5-enoic acid, C23H27N5O2, a mixed thromboxane A2 receptor antagonist and thromboxane A2 synthase inhibitor, shows a hairpin-like conformation stabilized by an intramolecular hydrogen bond. A structural feature characteristic of the thromboxane A2 synthase inhibitor mode is observed: a distance of 8.4257 (19) Å between the pyridine N atom and the carboxyl group.
翻译后摘要: terbogrel,(E)-6 - [4 - (3 - 叔丁基-2 - 氰基胍基) - 苯基] -6 - (3 - 吡啶基) - 己-5 - 烯酸,C23H27N5O2,混合的血栓素A2受体拮抗剂,血栓素A2合成酶抑制剂,示出了由分子内氢键稳定的发夹构象。血栓烷A2合成酶抑制剂模式的结构的特征特性的观察:8.4257(19)的距离埃之间的吡啶氮原子和羧基的。
Source: Acta Crystallographica Section C
Volume-OnPage: Volume 56 Issue 10  1265-1266
Publication Date: October 2000
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