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1905
Combined Tacrine and Estrogen Replacement Therapy in Patients with Alzheimer's Disease†‡
Combined Tacrine and Estrogen Replacement Therapy in Patients with Alzheimer's Disease†‡
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Yanyan Zhang, Monika Wittner, Hakim Bouamar, Peggy Jarrier, William Vainchenker and Fawzia Louache
2006
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ABSTRACT: In light of evidence that estrogen replacement might affect cholinergic function, we examined possible effects of estrogen replacement therapy (ERT) on clinical response to the cholinesterase inhibitor tacrine in women with Alzheimer's disease (AD). In a previously reported 30-week, randomized, double-blind, placebo-controlled, multicenter clinical trial, 14.5% of 318 women with evaluable data had been receiving ERT before randomization. They were randomly assigned to receive placebo ...
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