|
387
Macrophages and mesenchymal stromal cells support survival and proliferation of multiple myeloma cells
Macrophages and mesenchymal stromal cells support survival and proliferation of multiple myeloma cells
|
|
Ruian Xu, Xueying Sun, Lai-Yin Tse, Hua Li, Pui-Chung Chan, Sue Xu, Weidong Xiao, Hsiang-Fu Kung, Ge
2012
|
|
Multiple myeloma (MM) is characterized by almost exclusive tropism of malignant cells for the bone marrow (BM) milieu. The survival and proliferation of malignant plasma cells have been shown to rely on interactions with nonmalignant stromal cells, in particular mesenchymal stromal cells (MSCs), in the BM microenvironment. However, the BM microenvironment is composed of a diverse array of cell types. This study examined the role of macrophages, an abundant component of BM stroma, as a potential ...
|
| 查看全文
|
|
|