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Collagen in the cellular and fibrotic stages of scleroderma
Collagen in the cellular and fibrotic stages of scleroderma
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D.J. Struntz, W.A. McLellan, R.M. Dillaman, J.E. Blum, J.R. Kucklick and D.A. Pabst
2005
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The collagen in localized and systemic scleroderma skin was studied by light microscopy with silver impregnation (50 patients), electron microscopy (14 patients), and immunofluorescence microscopy using specific antibodies against Type I and Type III collagens (12 patients). In the cellular stage, the dermis and adipose tissue revealed perivascular or diffuse cellular infiltrates (mostly lymphocytes, plasma cells, and macrophages), accompanied by deposition of Type III collagen. The lower dermis...
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